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HPTN 035

Promising News on Microbicides Trial Results

Results of the HPTN 035 Study

Last updated: 24th February 2009

On 9th February 2009, the US National Institutes of Health announced promising results of a multi-site clinical trial of two candidate microbicides. Known as HPTN 035, the trial evaluated the safety and effectiveness of BufferGelģ and PRO 2000 (0.5 percent dose) for preventing male-to-female sexual transmission of HIV.

The trial found that women who were offered PRO2000 gel plus condoms had 30% fewer HIV infections than those offered only condoms or condoms plus a placebo gel. The other candidate microbicide tested, BufferGel, did not reduce HIV risk among women.

HPTN 035 Results Release Advocates Call Notes

Advocates' Frequently Asked Questions About HPTN 035
(Click here for the Word Version)

Click here to read GCMís press release

Microbicides Trials Network (MTN)

MTN is an HIV/AIDS clinical trials network established in 2006 by the US National Institutes of Health.

Click on the links below to read:

MTNís press release

MTNís Questions and Answers Document

MTNís fact sheet: HPTN 035 at a Glance

MTNís Background paper on HPTN 035

National Institute of Allergy & Infectious Diseases

The NIAID conducts and supports research--at NIH, throughout the United States, and worldwide--to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses.

Click on the links below to read:

NIAID press release

NIAID Questions & Answers

Additional Resources:

16th Conference on Retroviruses and Opportunistic Infections (CROI 2009)

Presentation on HPTN 035 Trial Results:"Safety and Effectiveness of Vaginal Microbicdies BufferGel and 0.5% PRO 2000/5 Gel for the Prevention of HIV Infection in Women: Results of the HPTN 035 Trial" (begin at slide #92)

Highlight: South Africaís Salim Abdool Karimís section is of great interest to microbicide advocates

The Alliance for Microbicides Development

Click here to read the statement issued by the Alliance for Microbicides Development (AMD)

The International Partnership for Microbicides

Click here to read the statement issued by the International Partnership for Microbicides (IPM).

Media Highlights:

New pills, gel may prevent HIV in women 11th February - The Times of India, New Delhi
Gel Vaginal Contra el Sida Muestra Eficacia 11th February - Los Tiempos, Bolivia
New Gel Shows Promise in AIDS Fight 11th February - The Sydney Morning Herald, Australia

A glimmer of hope for microbicide research

10th February - PlusNews Global

Microbicide Gel May Help Against HIV

10 February - Meredith Wadman, Nature

Drugs Are Found to Block HIV in Monkeys

10 February - David Brown, Washington Post

Microbicide reduces HIV infections by 30% in first success for field 9th February, Gus Crains & Micheal Carter, AIDSMap

Novel HIV-Fighting Method Finally Gels

9 February - Jon Cohen, Science